Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Natural antimicrobial peptides against Mycobacterium tuberculosis.
TB, caused by Mycobacterium tuberculosis, is one the leading infectious diseases worldwide. There is an urgent need to discover new drugs with unique structures and uncommon mechanisms of action to treat M. tuberculosis and combat antimycobacterial resistance. Naturally occurring compounds contain a wide diversity of chemical structures, displaying a wide range of in vitro potency towards M. tu...
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Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis with a MIC of 16 μg/ml. However, its efficacy against clinical isolates of M. tuberculosis has not been determined. We found that NTZ's MIC against 50 clinical isolates ranged from 12 to 28 μg/ml with a median of 16 μg/ml and was unaffected by resistance to first- or second-line antitu...
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Peptoids differ from peptides in that peptoids are composed of N-substituted rather than alpha-carbon-substituted glycine units. In this paper we report the in vitro and in vivo antibacterial activities of several antibacterial peptoids discovered by screening combinatorial chemistry libraries for bacterial growth inhibition. In vitro, the peptoid CHIR29498 and some of its analogues were active...
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background medicinal plants have been used traditionally in golestan province (north of iran), against mycobacterium tuberculosis or the clinical signs of tuberculosis (tb). objectives this study aimed to define the inhibitory effects of ethanolic extracts of six of these medicinal plants against mycobacterium tuberculosis. materials and methods peganum harmala (seed extract), punica granatum (...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2011
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01667-10